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- Title
Prospective study of combined treatment with interferon-alpha and active vitamin D<sub>3</sub> for Japanese patients with metastatic renal cell carcinoma.
- Authors
Obara, Wataru; Mizutani, Yoichi; Oyama, Chikara; Akaza, Hideyuki; Ishii, Nobuhisa; Kohri, Kenjiro; Namiki, Mikio; Okuyama, Akihiko; Shima, Hiroki; Yokoyama, Masayoshi; Shuin, Taro; Miki, Tsuneharu; Watanabe, Yoshiyuki; Fujioka, Tomoaki
- Abstract
Objectives: To assess the safety and efficacy of combined therapy with interferon-alpha (INF-α) and active vitamin D3 for metastatic renal cell carcinoma (RCC). Methods: Sixteen patients with metastatic RCC were enrolled in this prospective study. All received oral alfacalcidol (1 µg once daily) and INF-α (Sumiferon; 3 million units, three times a week). The primary endpoint was the response rate (defined as complete + partial remission). Secondary endpoints were cancer-specific survival and toxicity. The median follow-up period was 17 months (range: 5–49 months). Results: The median age of the patients was 68 years (range: 41–73 years). The sites of metastases were: lung in 13 patients, bone in one, lung and bone in one, and lung, bone, and lymph nodes in one. Four patients (25%) had a partial response (PR), 10 patients (62.5%) showed no change (NC), and two patients (12.5%) had progressive disease (PD). The median cancer-specific survival time was 45 months. One patient had to discontinue vitamin D3 because of hypercalcemia. Kaplan-Meier survival analysis revealed that metastasis at the time of initial diagnosis and older than average age were significant predictors of poor survival ( P < 0.05). Conclusions: Combined treatment with INF-α and active vitamin D3 has shown to be safe and effective for metastatic RCC patients.
- Subjects
CANCER patients; STEROID hormones; RENAL cell carcinoma; ANTINEOPLASTIC agents; CANCER invasiveness
- Publication
International Journal of Urology, 2008, Vol 15, Issue 9, p794
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/j.1442-2042.2008.02086.x