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- Title
Fetal dendritic cells give mum a break.
- Authors
Connor, Lisa M; Lamiable, Olivier; Ronchese, Franca
- Abstract
The article reports on a study which suggests that human fetal dendritic cells (DC) express high levels of enzyme Arginase-2 and inhibit tumor necrosis factor α (TNFα) production by allogeneic T cells. It discusses use of advanced flow cytometry, transcriptomics and cell culture to carry out analysis of fetal DC. It also mentions role of arginases in catabolizing the amino acid L-arginine and reducing its availability in the environment.
- Subjects
DENDRITIC cells; ARGINASE; TUMOR necrosis factors; T cells; FLOW cytometry; CELL culture; ARGININE
- Publication
Immunology & Cell Biology, 2017, Vol 95, Issue 7, p575
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1038/icb.2017.46