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- Title
Tissue localization and frequency of antigen-specific effector CD4<sup>+</sup> T cells determines the development of allergic airway inflammation.
- Authors
Harris, Nicola L.; Holloway, John; Fitzharris, Penny; McDonald, Michael; Camberis, Mali; de St. Groth, Barbara Fazekas; Ronchese, Franca; Le Gros, Graham
- Abstract
Previous activation of effector Th2 cells is central to the development of allergic inflammatory responses. We have observed that priming of allergen-specific Th2 cells in C57BL/6 or B10.A mice with allergen delivered via the i.p. or s.c. routes results in very different outcomes following subsequent airway exposure to the same allergen. Systemic allergen immunization (via the i.p. route) resulted in the formation of a lung-resident population of allergen-specific T cells, and mice developed severe allergic airway inflammation in response to inhaled allergen. The localization of cells to the lung did not require the presence of antigen at this site, but reflected a large pool of circulating activated allergen-specific T cells. In contrast, localized immunization (via the s.c. route) resulted in a small T-cell response restricted to the draining lymph node, and mice were not responsive to inhaled allergen. These data indicate that prior sensitization to an allergen alone was not sufficient for the induction of allergic inflammation; rather, responsiveness was largely determined by precursor frequency and tissue localization of the allergen-specific effector Th2 cells.
- Subjects
ANTIGENS; T cells; AIRWAY (Anatomy); INFLAMMATION; TH2 cells; ALLERGIES
- Publication
Immunology & Cell Biology, 2005, Vol 83, Issue 5, p490
- ISSN
0818-9641
- Publication type
Article
- DOI
10.1111/j.1440-1711.2005.01357.x