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- Title
The Transcription Factor T-Bet is Regulated by MicroRNA-155 in Murine Anti-Viral CD8<sup>+</sup> T Cells via SHIP-1.
- Authors
Hope, Jennifer L.; Stairiker, Christopher J.; Spantidea, Panagiota I.; Gracias, Donald T.; Carey, Alison J.; Fike, Adam J.; van Meurs, Marjan; Brouwers-Haspels, Inge; Rijsbergen, Laurine C.; Fraietta, Joseph A.; Mueller, Yvonne M.; Klop, Rosemarieke C.; Stelekati, Erietta; Wherry, E. John; Erkeland, Stefan J.; Katsikis, Peter D.
- Abstract
We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8+ T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8+ T cells is mediated by T-bet. T-bet levels in CTL were controlled in vivo by miR-155 via SH2 (Src homology 2)- containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in in vivo CTL responses and suggest an important signaling module that regulates effector CTL immunity.
- Subjects
ANTIVIRAL agents; TRANSCRIPTION factors; MICRORNA
- Publication
Frontiers in Immunology, 2017, p1
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2017.01696