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- Title
Therapeutic roles of carbon monoxide in intestinal ischemia-reperfusion injury.
- Authors
Katada, Kazuhiro; Takagi, Tomohisa; Uchiyama, Kazuhiko; Naito, Yuji
- Abstract
Intestinal ischemia-reperfusion (I-R) injury is a complex, multifactorial, pathophysiological process with high morbidity and mortality, leading to serious difficulty in treatment. The mechanisms involved in the pathogenesis of intestinal I-R injury have been examined in detail and various therapeutic approaches for intestinal I-R injury have been developed; however, existing circumstances have not yet led to a dramatic change of treatment. Carbon monoxide (CO), one of the by-products of heme degradation by heme oxygenase (HO), is considered as a candidate for treatment of intestinal I-R injury and indeed HO-1-derived endogenous CO and exogenous CO play a pivotal role in protecting the gastrointestinal tract from intestinal I-R injury. Interestingly, anti-inflammatory effects of CO have been elucidated sufficiently in various cell types including endothelial cells, circulating leukocytes, macrophages, lymphocytes, epithelial cells, fibroblast, organ-specific cells, and immune-presenting cells. In this review, we herein focus on the therapeutic roles of CO in intestinal I-R injury and the cell-specific anti-inflammatory effects of CO, clearly demonstrating future therapeutic strategies of CO for treating intestine I-R injury.
- Subjects
THERAPEUTIC use of carbon monoxide; INTESTINAL ischemia; TREATMENT of reperfusion injuries; CYTOPROTECTION; HEME oxygenase; OXIDATIVE stress; THERAPEUTICS
- Publication
Journal of Gastroenterology & Hepatology, 2015, Vol 30, Issue S1, p46
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.12742