We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Spatiotemporal expression and control of haemoglobin in space.
- Authors
Borg, Josef; Loy, Conor; Kim, JangKeun; Buhagiar, Alfred; Chin, Christopher; Damle, Namita; De Vlaminck, Iwijn; Felice, Alex; Liu, Tammy; Matei, Irina; Meydan, Cem; Muratani, Masafumi; Mzava, Omary; Overbey, Eliah; Ryon, Krista A.; Smith, Scott M.; Tierney, Braden T.; Trudel, Guy; Zwart, Sara R.; Beheshti, Afshin
- Abstract
It is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homoeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production. Haemoglobin biology provides an intriguing model for studying space omics, as it has been extensively explored at multiple -omic levels, spanning DNA, RNA, and protein analyses, in both experimental and clinical contexts. In this study, we examined the developmental expression of haemoglobin over time and space using a unique suite of multi-omic datasets available on NASA GeneLab, from the NASA Twins Study, the JAXA CFE study, and the Inspiration4 mission. Our findings reveal significant variations in globin gene expression corresponding to the distinct spatiotemporal characteristics of the collected samples. This study sheds light on the dynamic nature of globin gene regulation in response to the space environment and provides valuable insights into the broader implications of space omics research. Here the authors analyse the impact of space on haemoglobin gene regulation using data from NASA, JAXA and SpaceX i4 missions. They find that globin gene down-regulation leads to space anaemia with post-flight recovery, and reveal an adult-to-foetal globin switch activation.
- Subjects
GENE expression; UNITED States. National Aeronautics &; Space Administration; FETAL hemoglobin; SPACE Exploration Technologies Corp.; GLOBIN genes; HEMOGLOBINS; GENETIC regulation; SPACE environment; GLOBIN
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-49289-8