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- Title
Recent progress in the field of neoglycoconjugate chemistry.
- Authors
Jiménez-Castells, Carmen; Defaus, Sira; Andreu, David; Gutiérrez-Gallego, Ricardo
- Abstract
Glycosylation is probably the most complex secondary gene event that affects the vast majority of proteins in nature resulting in the occurrence of a heterogeneous mixture of glycoforms for a single protein. Many functions are exerted by single monosaccharides, well-defined oligosaccharides, or larger glycans present in these glycoproteins. To unravel these functions it is of the utmost importance to prepare well-defined single glycans conjugated to the underlying aglycon. In this review, the most recent developments are described to address the preparation of carbohydrate-amino acid (glyco-conjugates). Naturally occurring N- and O-linked glycosylation are described and the preparation of non-natural sugar-amino acid linkages are also included.
- Subjects
GLYCOSYLATION; MONOSACCHARIDES; GLYCOPROTEINS; POST-translational modification; PROTEINS; ERYTHROPOIETIN; GLYCOSYLTRANSFERASES; DENDRIMERS; FISSURELLIDAE
- Publication
Biomolecular Concepts, 2010, Vol 1, Issue 1, p85
- ISSN
1868-5021
- Publication type
Article
- DOI
10.1515/BMC.2010.007