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- Title
Liver-to-Spleen Ratio as an Index of Chronic Liver Diseases and Safety of Hepatectomy: A Pilot Study.
- Authors
Huang, Yangqing; Huang, Bin; Kan, Tong; Yang, Boshuai; Yuan, Min; Wang, Jiefei
- Abstract
Background: Hepatic failure is a main cause of death after hepatectomy. Accurate preoperative evaluation of functional liver reserve is the key to ensure safe resection. Studies have found that the spleen would gradually enlarge as chronic liver disease worsened. This study was designed to determine whether preoperative liver-to-spleen ratio (LSR) would be an indicator to evaluate severity of liver disease and predict safety of hepatectomy. Methods: The volumes of liver and spleen were evaluated on computed tomography scan in 67 patients who received partial hepatectomy. Preoperative LSR was calculated. Statistical analysis was conducted to examine the relationship between LSR and the degree of chronic liver disease. Ability of LSR to predict the safety of hepatectomy also was evaluated. Results: LSR had a negative correlation with the degree of chronic liver diseases ( r = −0.606, P < 0.0001). LSR = 3.22 was the cutoff point for predicting posthepatectomy complications and inadequacy. AUC, sensitivity, and specificity for predicting posthepatectomy complications and inadequacy respectively were 0.830 (95 % confidence interval [CI] 0.715-0.950, P < 0.0001), 69.6, 93.2 %, and 0.863 (95 % CI 0.777-0.949, P < 0.0001), 68.8, 84.3 %. Multivariate analysis showed that LSR = 3.22 was the factor that affected both posthepatectomy complications and liver inadequacy. Conclusions: Preoperative LSR score correlated well with the degree of chronic liver diseases, and it probably help us to improve the safety of hepatectomy.
- Subjects
LIVER diseases; CHRONIC diseases; HEPATECTOMY; LIVER surgery; OPERATIVE surgery; COMPUTED tomography; SAFETY
- Publication
World Journal of Surgery, 2014, Vol 38, Issue 12, p3186
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-014-2717-6