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- Title
Intensity‐modulated radiation therapy for nasal cavity and paranasal sinus tumors: Experience from a single institute.
- Authors
Laskar, Sarbani Ghosh; Pai, Prathamesh; Sinha, Shwetabh; Budrukkar, Ashwini; Nair, Deepa; Swain, Monali; Mummudi, Naveen; Gupta, Tejpal; Murthy, Vedang; Agarwal, Jai Prakash; Tiwari, Neelesh; Thiagrajan, Shiva; Chaukar, Devendra; Chaturvedi, Pankaj; Pantvaidya, Gouri; Deshmukh, Anuja; Nair, Sudhir; Prabhash, Kumar; Joshi, Amit; Noronha, Vanita
- Abstract
Background: To assess the efficacy of intensity‐modulated radiation therapy (IMRT) for tumors of the nasal cavity and paranasal sinus (PNS) region. Materials and Methods: Two hundred fourteen patients with tumors of the nasal cavity and PNS region treated with curative intent IMRT between 2007 and 2019 were included in this retrospective analysis. Results: Fifty‐one (24.1%) received definitive RT/CTRT and 163 (75.9%) received adjuvant RT. Most common histology was squamous cell carcinoma (26.1%) followed by adenoid cystic carcinoma (21.5%). The median follow‐up was 43.5 months. The 5‐year local control (LC), event‐free survival (EFS), and overall survival (OS) for the entire cohort was 66.9%, 59%, and 73.9%, respectively. On univariate analysis treatment with nonsurgical modality, T classification and undifferentiated/poorly differentiated histology were associated with inferior 5‐year LC, EFS, and OS. Four patients had late Grade 3/Grade 4 ocular toxicity. Conclusions: IMRT should be the standard of care for tumors of PNS region across all histologies and treatment setting.
- Subjects
NASAL cavity; PARANASAL sinuses; RADIOTHERAPY; OVERALL survival; ADENOID cystic carcinoma; OCULAR toxicology; NASAL tumors
- Publication
Head & Neck, 2021, Vol 43, Issue 7, p2045
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26669