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- Title
Detection rate of <sup>99m</sup>Tc-MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta-analysis.
- Authors
Treglia, Giorgio; Sadeghi, Ramin; Schalin–Jäntti, Camilla; Caldarella, Carmelo; Ceriani, Luca; Giovanella, Luca; Eisele, David W.
- Abstract
abstract Background Parathyroid scintigraphy using 99mTc-MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). The purpose of this review was to meta-analyze published data on the detection rate of 99mTc-MIBI SPECT/CT in the preoperative planning of patients with PHPT. Methods A comprehensive literature search of studies published through June 2014 was performed. The pooled detection rate of this scintigraphic method including 95% confidence intervals (95% CIs) was calculated on a per patient-based and on a per lesion-based analysis by using a random effects model. Results Twenty-three articles including 1236 patients with PHPT were selected. The pooled detection rate of 99mTc-MIBI SPECT/CT in the preoperative planning of patients with PHPT was 88% (95% CI = 84% to 92%) and 88% (95% CI = 82% to 92%) on a per patient-based and per lesion-based analysis, respectively. Conclusion The 99mTc-MIBI SPECT/CT has high detection rate for hyperfunctioning parathyroid glands in patients with PHPT. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2159-E2172, 2016
- Subjects
HYPERPARATHYROIDISM; SINGLE-photon emission computed tomography; META-analysis; CONFIDENCE intervals; RANDOM effects model; DIAGNOSIS
- Publication
Head & Neck, 2016, Vol 38, pE2159
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24027