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- Title
Cytotoxic T-lymphocyte Antigen-4 Polymorphisms and Susceptibility to Osteosarcoma.
- Authors
Liu, Yang; He, Zhimin; Feng, Dapeng; Shi, Guodong; Gao, Rui; Wu, Xiaodong; Song, Weiguo; Yuan, Wen
- Abstract
Despite the knowledge of many genetic alterations present in osteosarcoma, the complexity of this disease precludes placing its biology into a simple conceptual framework. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles in downregulating T-cell activation, thereby attenuating anti-tumor responses and increasing cancer susceptibility. Polymorphisms in the CTLA-4 gene are associated with different autoimmune diseases and cancers. The current study evaluated the association of four CTLA-4 gene mutations, −1661A/G (rs4553808), −318C/T (rs5742909), +49G/A (rs231775), and CT60A/G (rs3087243), with osteosarcoma in the Chinese population. CTLA-4 polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 267 osteosarcoma patients and 282 age-matched healthy controls. Results showed that the CTLA-4 gene +49 AA genotype, +49 A allele, and GTAG haplotype were significantly more frequent in osteosarcoma patients than in controls (odds ratio [OR] 2.20, 95% confidence interval [CI] 1.23-2.95, p = 0.007; OR 1.32, 95% CI 1.03-1.69, p = 0.029, and OR = 1.47, 95% CI 1.03-2.09, p = 0.033, respectively). The CTLA-4 +49G/A polymorphism and GTAG haplotype are associated with increased risk of osteosarcoma.
- Subjects
OSTEOSARCOMA; BONE cancer; T cells; GENETIC polymorphisms; CANCER; POLYMERASE chain reaction; AUTOIMMUNE diseases
- Publication
DNA & Cell Biology, 2011, Vol 30, Issue 12, p1051
- ISSN
1044-5498
- Publication type
Article
- DOI
10.1089/dna.2011.1269