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- Title
Mentation Tracks Severity but not Oxygenation in Obstructive Sleep Apnea.
- Authors
McCloskey, Lawrence C.
- Abstract
There is a rough consensus, after decades of research, that obstructive sleep apnea (OSA) is associated with mild cognitive impairments, especially in areas of executive functioning (EF), attention/working memory (A/WM), episodic memory (EM), and speed of speed of information processing (SIP). However, there is less consensus as to whether apnea severity matters for these impairments, which sleep variables matter most to which cognitive domains, whether common OSA comorbidities contribute to these determinations, or whether the apparent associations are really artifacts of these comorbidities. In this study, 40 participants with OSA submitted to polysomnography and to neuropsychological assessment with an expanded Halstead-Reitan Test Battery. Aggregates of tests to cover the four cognitive domains mentioned above were linearly regressed on the apnea-hypopnea index (AHI), the nadir of oxygen saturation (NOS), and hypertension and diabetes mellitus (scored present or absent). The AHI predicted both EF (p =.015; sr2 =.13) and A/WM (p =.023; sr2 = 11) in the primary analyses, and EM (p =.027; sr2 =.10) in the secondary analyses. Thus, AHI may affect EF, A/WM and perhaps EM beyond NOS and beyond two of OSA's most common comorbidities. Implications of these findings are discussed here.
- Subjects
PENNSYLVANIA; COGNITION disorders; EXECUTIVE function; THOUGHT &; thinking; NEUROPSYCHOLOGY; COGNITIVE processing speed; REGRESSION analysis; POLYSOMNOGRAPHY; SLEEP apnea syndromes; SHORT-term memory; DESCRIPTIVE statistics; REACTIVE oxygen species; OXYGEN in the body; DISEASE complications
- Publication
Perceptual & Motor Skills, 2023, Vol 130, Issue 3, p1139
- ISSN
0031-5125
- Publication type
Article
- DOI
10.1177/00315125231170025