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- Title
Epstein-Barr virus-associated pneumonia and bronchiolitis obliterans syndrome in a lung transplant recipient.
- Authors
Krumbholz, Andi; Sandhaus, Tim; Göhlert, Angela; Heim, Albert; Zell, Roland; Egerer, Renate; Breuer, Martin; Straube, Eberhard; Wutzler, Peter; Sauerbrei, Andreas
- Abstract
We report the case of a 25-year-old lung and liver transplant recipient who developed respiratory failure. High levels of Epstein-Barr virus (EBV) genome copies were detectable in respiratory tract specimens, while the search for various other viral, bacterial or fungal pathogens remained empty. Post-transplant lymphoproliferative disease was excluded. Due to the rapid progression of respiratory insufficiency, a re-transplantation of the lung was performed. EBV-encoded small RNAs could be demonstrated by in situ hybridization within pneumocytes and lymphocytes of the explanted lung tissue. The clinical situation improved soon after re-transplantation, and the EBV load detected in the lower respiratory tract decreased significantly.
- Subjects
EPSTEIN-Barr virus; GENOMES; PNEUMONIA; LUNG transplantation; MEDICAL microbiology
- Publication
Medical Microbiology & Immunology, 2010, Vol 199, Issue 4, p317
- ISSN
0300-8584
- Publication type
Article
- DOI
10.1007/s00430-010-0165-y