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Versatile roles of extracellular vesicles in cancer.
Published in:
2016
By:
- Nobuyoshi Kosaka;
- Yusuke Yoshioka;
- Yu Fujita;
- Takahiro Ochiya;
- Kosaka, Nobuyoshi;
- Yoshioka, Yusuke;
- Fujita, Yu;
- Ochiya, Takahiro
Publication type:
journal article
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk.
Published in:
Journal of Extracellular Vesicles, 2021, v. 10, n. 10, p. 1, doi. 10.1002/jev2.12124
By:
- Kadota, Tsukasa;
- Fujita, Yu;
- Araya, Jun;
- Watanabe, Naoaki;
- Fujimoto, Shota;
- Kawamoto, Hironori;
- Minagawa, Shunsuke;
- Hara, Hiromichi;
- Ohtsuka, Takashi;
- Yamamoto, Yusuke;
- Kuwano, Kazuyoshi;
- Ochiya, Takahiro
Publication type:
Article
Early prediction of COVID‐19 severity using extracellular vesicle COPB2.
Published in:
Journal of Extracellular Vesicles, 2021, v. 10, n. 8, p. 1, doi. 10.1002/jev2.12092
By:
- Fujita, Yu;
- Hoshina, Tokio;
- Matsuzaki, Juntaro;
- Yoshioka, Yusuke;
- Kadota, Tsukasa;
- Hosaka, Yusuke;
- Fujimoto, Shota;
- Kawamoto, Hironori;
- Watanabe, Naoaki;
- Sawaki, Kenji;
- Sakamoto, Yohei;
- Miyajima, Makiko;
- Lee, Kwangyole;
- Nakaharai, Kazuhiko;
- Horino, Tetsuya;
- Nakagawa, Ryo;
- Araya, Jun;
- Miyato, Mitsuru;
- Yoshida, Masaki;
- Kuwano, Kazuyoshi
Publication type:
Article
Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis.
Published in:
Journal of Extracellular Vesicles, 2015, v. 4, p. 1, doi. 10.3402/jev.v4.28388
By:
- Fujita, Yu;
- Araya, Jun;
- Ito, Saburo;
- Kobayashi, Kenji;
- Kosaka, Nobuyoshi;
- Yoshioka, Yusuke;
- Kadota, Tsukasa;
- Hara, Hiromichi;
- Kuwano, Kazuyoshi;
- Ochiya, Takahiro
Publication type:
Article
RNAi Therapeutic Platforms for Lung Diseases.
Published in:
Pharmaceuticals (14248247), 2013, v. 6, n. 2, p. 223, doi. 10.3390/ph6020223
By:
- Fujita, Yu;
- Takeshita, Fumitaka;
- Kuwano, Kazuyoshi;
- Ochiya, Takahiro
Publication type:
Article
Extracellular Vesicles in Chronic Obstructive Pulmonary Disease.
Published in:
International Journal of Molecular Sciences, 2016, v. 17, n. 11, p. 1801, doi. 10.3390/ijms17111801
By:
- Tsukasa Kadota;
- Yu Fujita;
- Yusuke Yoshioka;
- Jun Araya;
- Kazuyoshi Kuwano;
- Takahiro Ochiya
Publication type:
Article
Development of Small RNA Delivery Systems for Lung Cancer Therapy.
Published in:
International Journal of Molecular Sciences, 2015, v. 16, n. 3, p. 5254, doi. 10.3390/ijms16035254
By:
- Yu Fujita;
- Kazuyoshi Kuwano;
- Takahiro Ochiya
Publication type:
Article
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25664-7
By:
- Khateb, Ali;
- Deshpande, Anagha;
- Feng, Yongmei;
- Finlay, Darren;
- Lee, Joo Sang;
- Lazar, Ikrame;
- Fabre, Bertrand;
- Li, Yan;
- Fujita, Yu;
- Zhang, Tongwu;
- Yin, Jun;
- Pass, Ian;
- Livneh, Ido;
- Jeremias, Irmela;
- Burian, Carol;
- Mason, James R.;
- Almog, Ronit;
- Horesh, Nurit;
- Ofran, Yishai;
- Brown, Kevin
Publication type:
Article
Voltage unbalance suppression method in distribution line by constantly installing capacitor.
Published in:
IEEJ Transactions on Electrical & Electronic Engineering, 2020, v. 15, n. 5, p. 816, doi. 10.1002/tee.23123
By:
- Fujita, Yu;
- Kobayashi, Hiroshi;
- Aoki, Mutsumi;
- Uenishi, Hirokazu
Publication type:
Article
Role of NPxY motif in Draper-mediated apoptotic cell clearance in Drosophila.
Published in:
Drug Discoveries & Therapeutics, 2012, v. 6, n. 6, p. 291, doi. 10.5582/ddt.2012.v6.6.291
By:
- Fujita, Yu;
- Nagaosa, Kaz;
- Shiratsuchi, Akiko;
- Nakanishi, Yoshinobu
Publication type:
Article
Metformin attenuates lung fibrosis development via NOX4 suppression.
Published in:
Respiratory Research, 2016, v. 17, p. 1, doi. 10.1186/s12931-016-0420-x
By:
- Nahoko Sato;
- Naoki Takasaka;
- Masahiro Yoshida;
- Kazuya Tsubouchi;
- Shunsuke Minagawa;
- Jun Araya;
- Nayuta Saito;
- Yu Fujita;
- Yusuke Kurita;
- Kenji Kobayashi;
- Saburo Ito;
- Hiromichi Hara;
- Tsukasa Kadota;
- Haruhiko Yanagisawa;
- Mitsuo Hashimoto;
- Hirofumi Utsumi;
- Hiroshi Wakui;
- Jun Kojima;
- Takanori Numata;
- Yumi Kaneko
Publication type:
Article
Successful treatment of steroid-refractory immune checkpoint inhibitor-related pneumonitis with triple combination therapy: a case report.
Published in:
Cancer Immunology, Immunotherapy, 2020, v. 69, n. 10, p. 2033, doi. 10.1007/s00262-020-02600-0
By:
- Utsumi, Hirofumi;
- Araya, Jun;
- Okuda, Keitaro;
- Watanabe, Junko;
- Takekoshi, Daisuke;
- Fujita, Yu;
- Hashimoto, Mitsuo;
- Wakui, Hiroshi;
- Minagawa, Shunsuke;
- Numata, Takanori;
- Hara, Hiromichi;
- Kuwano, Kazuyoshi
Publication type:
Article
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5<sup>−/−</sup> mice.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09525-y
By:
- Li, Yan;
- Tinoco, Roberto;
- Elmén, Lisa;
- Segota, Igor;
- Xian, Yibo;
- Fujita, Yu;
- Sahu, Avinash;
- Zarecki, Raphy;
- Marie, Kerrie;
- Feng, Yongmei;
- Khateb, Ali;
- Frederick, Dennie T.;
- Ashkenazi, Shiri K.;
- Kim, Hyungsoo;
- Perez, Eva Guijarro;
- Day, Chi-Ping;
- Segura Muñoz, Rafael S.;
- Schmaltz, Robert;
- Yooseph, Shibu;
- Tam, Miguel A.
Publication type:
Article
Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma.
Published in:
Cancers, 2019, v. 11, n. 6, p. 768, doi. 10.3390/cancers11060768
By:
- Kawamoto, Hironori;
- Hara, Hiromichi;
- Araya, Jun;
- Ichikawa, Akihiro;
- Fujita, Yu;
- Utsumi, Hirofumi;
- Hashimoto, Mitsuo;
- Wakui, Hiroshi;
- Minagawa, Shunsuke;
- Numata, Takanori;
- Arihiro, Seiji;
- Matsuura, Tomokazu;
- Fujiwara, Mutsunori;
- Ito, Satoru;
- Kuwano, Kazuyoshi
Publication type:
Article
Effectiveness of Switching Biologics for Severe Asthma Patients in Japan: A Single-Center Retrospective Study.
Published in:
Journal of Asthma & Allergy, 2021, v. 14, p. 609, doi. 10.2147/JAA.S311975
By:
- Numata, Takanori;
- Araya, Jun;
- Miyagawa, Hanae;
- Okuda, Keitaro;
- Fujita, Yu;
- Utsumi, Hirofumi;
- Takekoshi, Daisuke;
- Hashimoto, Mitsuo;
- Minagawa, Shunsuke;
- Ishikawa, Takeo;
- Hara, Hiromichi;
- Kuwano, Kazuyoshi
Publication type:
Article
ATP increases the migration of microglia across the brain endothelial cell monolayer.
Published in:
Bioscience Reports, 2016, v. 36, n. 2, p. 1, doi. 10.1042/BSR20160054
By:
- Tomoji Maeda;
- Manato Inagaki;
- Yu Fujita;
- Takehiro Kimoto;
- Chiaki Tanabe-Fujimura;
- Kun Zou;
- Junjun Liu;
- Shuyu Liu;
- Hiroto Komano
Publication type:
Article
Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.
Published in:
EMBO Journal, 2018, v. 37, n. 20, p. N.PAG, doi. 10.15252/embj.201899735
By:
- Pathria, Gaurav;
- Scott, David A;
- Feng, Yongmei;
- Sang Lee, Joo;
- Fujita, Yu;
- Zhang, Gao;
- Sahu, Avinash D;
- Ruppin, Eytan;
- Herlyn, Meenhard;
- Osterman, Andrei L;
- Ronai, Ze'ev A
Publication type:
Article
Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells.
Published in:
EMBO Journal, 2009, v. 28, n. 24, p. 3868, doi. 10.1038/emboj.2009.343
By:
- Kuraishi, Takayuki;
- Nakagawa, Yukiko;
- Nagaosa, Kaz;
- Hashimoto, Yumi;
- Ishimoto, Takashi;
- Moki, Takeshi;
- Fujita, Yu;
- Nakayama, Hiroshi;
- Dohmae, Naoshi;
- Shiratsuchi, Akiko;
- Yamamoto, Naoko;
- Ueda, Koichi;
- Yamaguchi, Masamitsu;
- Awasaki, Takeshi;
- Nakanishi, Yoshinobu
Publication type:
Article
Stress-Induced Suppression of Milk Protein Is Involved in a Noradrenergic Mechanism in the Mammary Gland.
Published in:
Endocrinology, 2019, v. 160, n. 9, p. 2074, doi. 10.1210/en.2019-00300
By:
- Chiba, Takeshi;
- Maeda, Tomoji;
- Fujita, Yu;
- Takeda, Rika;
- Kikuchi, Akihiko;
- Kudo, Kenzo
Publication type:
Article
Fibroblast-derived Extracellular Vesicles Induce Lung Cancer Progression in the Idiopathic Pulmonary Fibrosis Microenvironment.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2023, v. 69, n. 1, p. 34, doi. 10.1165/rcmb.2022-0253OC
By:
- Yu Fujita;
- Shota Fujimoto;
- Atsushi Miyamoto;
- Reika Kaneko;
- Tsukasa Kadota;
- Naoaki Watanabe;
- Ryusuke Kizawa;
- Hironori Kawamoto;
- Junko Watanabe;
- Hirofumi Utsumi;
- Hiroshi Wakui;
- Shunsuke Minagawa;
- Jun Araya;
- Takashi Ohtsuka;
- Takahiro Ochiya;
- Kazuyoshi Kuwano
Publication type:
Article
Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2022, v. 67, n. 6, p. 708, doi. 10.1165/rcmb.2021-0555OC
By:
- Naoaki Watanabe;
- Yu Fujita;
- Jun Nakayama;
- Yutaro Mori;
- Tsukasa Kadota;
- Yusuke Hayashi;
- Iwao Shimomura;
- Takashi Ohtsuka;
- Koji Okamoto;
- Jun Araya;
- Kazuyoshi Kuwano;
- Yusuke Yamamoto
Publication type:
Article
Extracellular Vesicles from Fibroblasts Induce Epithelial-Cell Senescence in Pulmonary Fibrosis.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2020, v. 63, n. 5, p. 623, doi. 10.1165/rcmb.2020-0002OC
By:
- Tsukasa Kadota;
- Yusuke Yoshioka;
- Yu Fujita;
- Jun Araya;
- Shunsuke Minagawa;
- Hiromichi Hara;
- Atsushi Miyamoto;
- Souichiro Suzuki;
- Sakashi Fujimori;
- Tadasu Kohno;
- Takeshi Fujii;
- Kazuma Kishi;
- Kazuyoshi Kuwano;
- Takahiro Ochiya
Publication type:
Article
Extracellular Vesicles: New Players in Lung Immunity.
Published in:
American Journal of Respiratory Cell & Molecular Biology, 2018, v. 58, n. 5, p. 560, doi. 10.1165/rcmb.2017-0293TR
By:
- Yu Fujita;
- Tsukasa Kadota;
- Jun Araya;
- Takahiro Ochiya;
- Kazuyoshi Kuwano
Publication type:
Article
Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy.
Published in:
2017
By:
- Yusuke Kurita;
- Jun Araya;
- Shunsuke Minagawa;
- Hiromichi Hara;
- Akihiro Ichikawa;
- Nayuta Saito;
- Tsukasa Kadota;
- Kazuya Tsubouchi;
- Nahoko Sato;
- Masahiro Yoshida;
- Kenji Kobayashi;
- Saburo Ito;
- Yu Fujita;
- Hirofumi Utsumi;
- Haruhiko Yanagisawa;
- Mitsuo Hashimoto;
- Hiroshi Wakui;
- Yutaka Yoshii;
- Takeo Ishikawa;
- Takanori Numata
Publication type:
journal article
The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer.
Published in:
Molecular Therapy, 2015, v. 23, n. 4, p. 717, doi. 10.1038/mt.2015.10
By:
- Fujita, Yu;
- Yagishita, Shigehiro;
- Hagiwara, Keitaro;
- Yoshioka, Yusuke;
- Kosaka, Nobuyoshi;
- Takeshita, Fumitaka;
- Fujiwara, Tomohiro;
- Tsuta, Koji;
- Nokihara, Hiroshi;
- Tamura, Tomohide;
- Asamura, Hisao;
- Kawaishi, Makoto;
- Kuwano, Kazuyoshi;
- Ochiya, Takahiro
Publication type:
Article
Analysis of Measured Data in Unbalanced Distribution System and Method of Making of Distribution System Model for Analyzing.
Published in:
Electrical Engineering in Japan, 2017, v. 199, n. 1, p. 19, doi. 10.1002/eej.22960
By:
- FUJITA, YU;
- KOBAYASHI, HIROSHI;
- KODERA, TAKANORI;
- AOKI, MUTSUMI;
- SUZUKI, HIROTO;
- ISHIKAWA, HIROYUKI;
- MIWA, TAKURO
Publication type:
Article
Exploratory analysis to predict pneumonitis during durvalumab consolidation therapy for patients with locally advanced non‐small cell lung cancer from proteomic profiling of circulating extracellular vesicles.
Published in:
Thoracic Cancer, 2023, v. 14, n. 29, p. 2909, doi. 10.1111/1759-7714.15077
By:
- Torasawa, Masahiro;
- Horinouchi, Hidehito;
- Yagishita, Shigehiro;
- Utsumi, Hirofumi;
- Okuda, Keitaro;
- Takekoshi, Daisuke;
- Ito, Saburo;
- Wakui, Hiroshi;
- Murata, Saori;
- Kaku, Sawako;
- Okuma, Kae;
- Matsumoto, Yuji;
- Shinno, Yuki;
- Okuma, Yusuke;
- Yoshida, Tatsuya;
- Goto, Yasushi;
- Yamamoto, Noboru;
- Araya, Jun;
- Ohe, Yuichiro;
- Fujita, Yu
Publication type:
Article
Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper.
Published in:
Journal of Biochemistry, 2013, v. 153, n. 5, p. 483, doi. 10.1093/jb/mvt014
By:
- Tung, Tran Thanh;
- Nagaosa, Kaz;
- Fujita, Yu;
- Kita, Asana;
- Mori, Hiroki;
- Okada, Ryo;
- Nonaka, Saori;
- Nakanishi, Yoshinobu
Publication type:
Article
Multicenter Pharmacokinetic and Pharmacodynamic Study of Pembrolizumab for Non‐small‐Cell Lung Cancer in Patients Aged 75 Years and Older.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 4, p. 1042, doi. 10.1002/cpt.3339
By:
- Yagishita, Shigehiro;
- Yamanaka, Yuta;
- Kurata, Takayasu;
- Watanabe, Kageaki;
- Hosomi, Yukio;
- Horinouchi, Hidehito;
- Ohe, Yuichiro;
- Nakahara, Yoshiro;
- Naoki, Katsuhiko;
- Asao, Tetsuhiko;
- Takahashi, Kazuhisa;
- Saeki, Sho;
- Sakagami, Takuro;
- Nakashima, Kazuhisa;
- Tsubata, Yukari;
- Fujita, Yu;
- Wakui, Hiroshi;
- Furuta, Megumi;
- Konishi, Jun Sakakibara;
- Ohuchi, Mayu
Publication type:
Article
Characterization of cis‐regulatory elements for Fgf10 expression in the chick embryo.
Published in:
Developmental Dynamics, 2018, v. 247, n. 12, p. 1253, doi. 10.1002/dvdy.24682
By:
- Kawakami, Hiroko;
- Johnson, Austin;
- Fujita, Yu;
- Swearer, Avery;
- Wada, Naoyuki;
- Kawakami, Yasuhiko
Publication type:
Article
Divergent roles of the Hippo pathway in the pathogenesis of idiopathic pulmonary fibrosis: tissue homeostasis and fibrosis.
Published in:
Inflammation & Regeneration, 2023, v. 43, n. 1, p. 1, doi. 10.1186/s41232-023-00295-1
By:
- Kizawa, Ryusuke;
- Araya, Jun;
- Fujita, Yu
Publication type:
Article
Extracellular vesicles in idiopathic pulmonary fibrosis: pathogenesis and therapeutics.
Published in:
Inflammation & Regeneration, 2022, v. 42, n. 1, p. 1, doi. 10.1186/s41232-022-00210-0
By:
- Fujita, Yu
Publication type:
Article
Role of chaperone-mediated autophagy in the pathophysiology including pulmonary disorders.
Published in:
Inflammation & Regeneration, 2021, v. 41, n. 1, p. 1, doi. 10.1186/s41232-021-00180-9
By:
- Hosaka, Yusuke;
- Araya, Jun;
- Fujita, Yu;
- Kuwano, Kazuyoshi
Publication type:
Article
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88870-9
By:
- Fujita, Yu;
- Kano, Kuniyuki;
- Kishino, Shigenobu;
- Nagao, Toshihiro;
- Shen, Xuefeng;
- Sato, Chiharu;
- Hatakeyama, Hatsune;
- Ota, Yume;
- Niibori, Sho;
- Nomura, Ayako;
- Kikuchi, Kota;
- Yasuno, Wataru;
- Takatori, Sho;
- Kikuchi, Kazunori;
- Sano, Yoshitake;
- Tomita, Taisuke;
- Suzuki, Toshiharu;
- Aoki, Junken;
- Zou, Kun;
- Natori, Shunji
Publication type:
Article
Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration.
Published in:
European Respiratory Review, 2022, v. 31, n. 163, p. 1, doi. 10.1183/16000617.0106-2021
By:
- Tsukasa Kadota;
- Yu Fujita;
- Jun Araya;
- Takahiro Ochiya;
- Kazuyoshi Kuwano
Publication type:
Article
N-Glycosylation of the Drosophila neural protein Chaoptin is essential for its stability, cell surface transport and adhesive activity
Published in:
FEBS Letters, 2008, v. 582, n. 17, p. 2572, doi. 10.1016/j.febslet.2008.06.028
By:
- Hirai-Fujita, Yu;
- Yamamoto-Hino, Miki;
- Kanie, Osamu;
- Goto, Satoshi
Publication type:
Article
Involvement of Parkin‐mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease‐related sarcopenia.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 3, p. 1864, doi. 10.1002/jcsm.12988
By:
- Ito, Akihiko;
- Hashimoto, Mitsuo;
- Tanihata, Jun;
- Matsubayashi, Sachi;
- Sasaki, Ryoko;
- Fujimoto, Shota;
- Kawamoto, Hironori;
- Hosaka, Yusuke;
- Ichikawa, Akihiro;
- Kadota, Tsukasa;
- Fujita, Yu;
- Takekoshi, Daisuke;
- Ito, Sabro;
- Minagawa, Shunsuke;
- Numata, Takanori;
- Hara, Hiromichi;
- Matsuoka, Tatsuki;
- Udaka, Jun;
- Araya, Jun;
- Saito, Mitsuru
Publication type:
Article
Chaperone‐mediated autophagy receptor modulates tumor growth and chemoresistance in non–small cell lung cancer.
Published in:
Cancer Science, 2020, v. 111, n. 11, p. 4154, doi. 10.1111/cas.14629
By:
- Ichikawa, Akihiro;
- Fujita, Yu;
- Hosaka, Yusuke;
- Kadota, Tsukasa;
- Ito, Akihiko;
- Yagishita, Shigehiro;
- Watanabe, Naoaki;
- Fujimoto, Shota;
- Kawamoto, Hironori;
- Saito, Nayuta;
- Yoshida, Masahiro;
- Hashimoto, Mitsuo;
- Minagawa, Shunsuke;
- Hara, Hiromichi;
- Motoi, Noriko;
- Yamamoto, Yusuke;
- Ochiya, Takahiro;
- Araya, Jun;
- Kuwano, Kazuyoshi
Publication type:
Article
Extracellular vesicle transfer of cancer pathogenic components.
Published in:
Cancer Science, 2016, v. 107, n. 4, p. 385, doi. 10.1111/cas.12896
By:
- Fujita, Yu;
- Yoshioka, Yusuke;
- Ochiya, Takahiro
Publication type:
Article
The Impact of Extracellular Vesicle-Encapsulated Circulating MicroRNAs in Lung Cancer Research.
Published in:
BioMed Research International, 2014, v. 2014, p. 1, doi. 10.1155/2014/486413
By:
- Yu Fujita;
- Kazuyoshi Kuwano;
- Takahiro Ochiya;
- Fumitaka Takeshita
Publication type:
Article

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