We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
18F-fluorocholine versus 18F-fluorodeoxyglucose for PET/CT imaging in patients with suspected relapsing or progressive multiple myeloma: a pilot study.
- Authors
Cassou-Mounat, Thibaut; Balogova, Sona; Nataf, Valérie; Calzada, Marie; Huchet, Virginie; Kerrou, Khaldoun; Devaux, Jean-Yves; Mohty, Mohamad; Talbot, Jean-Noël; Garderet, Laurent
- Abstract
Purpose: Hybrid positron emission tomography/computed tomography (PET/CT) has now become available, as well as whole-body, low-dose multidetector row computed tomography (MDCT) or magnetic resonance imaging (MRI). The radioactive glucose analogue 18F-fluorodeoxyglucose (FDG) is the most widely used tracer but has a relatively low sensitivity in detecting multiple myeloma (MM). We compared FDG with a more recent metabolic tracer, 18F-fluorocholine (FCH), for the detection of MM lesions at time of disease relapse or progression. Methods: We analyzed the results of FDG and FCH imaging in 21 MM patients undergoing PET/CT for suspected relapsing or progressive MM. For each patient and each tracer, an on-site reader and a masked reader independently determined the number of intraosseous and extraosseous foci of tracer and the intensity of uptake as measured by their SUVmax and the corresponding target/non-target ratio (T/NT). Results: In the skeleton of 21 patients, no foci were found for two cases, uncountable foci were observed in four patients, including some mismatched FCH/FDG foci. In the 15 patients with countable bone foci, the on-site reader detected 72 FDG foci vs. 127 FCH foci (+76 %), whereas the masked reader detected 69 FDG foci vs. 121 FCH foci (+75 %), both differences being significant. Interobserver agreement on the total number of bone foci was very high, with a kappa coefficient of 0.81 for FDG and 0.89 for FCH. Measurement of uptake in the matched foci that took up both tracers revealed a significantly higher median SUVmax and T/NT for FCH vs. FDG. Almost all unmatched foci were FCH-positive FDG-negative (57/59 = 97 % on-site and 56/60 = 93 % on masked reading); they were more frequently observed than matched foci in the head and neck region. Conclusions: These findings suggest that PET/CT performed for suspected relapsing or progressive MM would reveal more lesions when using FCH rather than FDG.
- Subjects
TRACERS (Chemistry); POSITRON emission tomography; COMPUTED tomography; MEDICAL imaging systems; MAGNETIC resonance imaging; FLUORODEOXYGLUCOSE F18; MULTIPLE myeloma
- Publication
European Journal of Nuclear Medicine & Molecular Imaging, 2016, Vol 43, Issue 11, p1995
- ISSN
1619-7070
- Publication type
Article
- DOI
10.1007/s00259-016-3392-7