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- Title
Synthesis of Glycyrrhizic Acid Conjugates with Amino-Acid Methyl Esters and their Ability to Stimulate Antibody Genesis in Mice.
- Authors
Baltina, L. A.; Baltina Jr, L. A.; Petrova, S. F.; Gabdrakhmanova, S. F.; Makara, N. S.; Sapozhnikova, T. A.
- Abstract
Conjugates of glycyrrhizic acid (GA) with methyl esters of L-amino acids (valine, methionine, and glutamic acid) containing the amino-acid residues in the carbohydrate moiety of the glycoside were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The resulting GA conjugates at a dose of 2 mg/kg stimulated a primary immune response (production of antibody-forming cells, AFCs) in outbred mice by 1.6 – 3 times as compared with the control. The conjugate of GA with Glu(OMe)2 stimulated antibody genesis in outbred mice 1.7 times more efficiently than N-acetylmuramyl dipeptide and showed a stimulating effect on AFC production in the spleen of CBA mice.
- Subjects
GLUTAMIC acid; MICE; ACIDS; IMMUNOGLOBULINS; GLATIRAMER acetate; METHYL formate; IMMUNE response
- Publication
Pharmaceutical Chemistry Journal, 2022, Vol 56, Issue 7, p894
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-022-02724-w