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- Title
Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines.
- Authors
Mokrov, G. V.; Likhosherstov, A. M.; Barchukov, V. V.; Stolyaruk, V. N.; Tsorin, I. B.; Vititnova, M. B.; Rebeko, A. G.; Kryzhanovskii, S. A.; Gudasheva, T. A.
- Abstract
A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.
- Subjects
PIPERAZINE; ARRHYTHMIA
- Publication
Pharmaceutical Chemistry Journal, 2019, Vol 53, Issue 9, p786
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-019-02080-2