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- Title
Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms.
- Authors
Zhang, Dapeng; Iyer, Lakshminarayan M.; Aravind, L.
- Abstract
Summary: Gibberellic acids (GAs) are key plant hormones, regulating various aspects of growth and development, which have been at the center of the ‘green revolution’. GRAS family proteins, the primary players in GA signaling pathways, remain poorly understood. Using sequence-profile searches, structural comparisons and phylogenetic analysis, we establish that the GRAS family first emerged in bacteria and belongs to the Rossmann fold methyltransferase superfamily. All bacterial and a subset of plant GRAS proteins are likely to function as small-molecule methylases. The remaining plant versions have lost one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. We predict that GRAS proteins might either modify or bind small molecules such as GAs or their derivatives.Contact: aravind@ncbi.nlm.nih.govSupplementary Information: Supplementary Material for this article is available at Bioinformatics online.
- Subjects
GIBBERELLIC acid; PROTEIN analysis; PLANT hormones; METHYLTRANSFERASES; NUCLEOTIDE sequence; COMPARATIVE studies
- Publication
Bioinformatics, 2012, Vol 28, Issue 19, p2407
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/bts464