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- Title
Dysregulation of toll-like receptor ( TLR) 2 expression on monocytes and upregulation of the frequency of T cells expressing TLR2 in patients with chronic hepatitis C virus infection.
- Authors
Ronit, Andreas; Salem, Mohammad; Hartling, Hans J.; Gaardbo, Julie C.; Ullum, Henrik; Gerstoft, Jan; Nielsen, Susanne D.
- Abstract
Toll-like receptors ( TLRs) initiate inflammatory responses that may play a role in disease progression in patients infected with hepatitis C virus ( HCV). TLR2 and TLR4 surface expression were assessed on CD14+ monocytes, CD4+ and CD8+ T cells in treatment naïve patients with chronic HCV infection with fibrosis, without fibrosis, co-infected with human immunodeficiency virus ( HIV), and in healthy controls. Increased expression of TLR2 was found on monocytes in HCV-infected patients with fibrosis (p < 0.01), co-infected with HIV (p = 0.03), and possibly in patients without fibrosis (p = 0.07) when compared to controls. TLR2 positive CD4+ and CD8+ T cells were upregulated in patients with fibrosis only (p < 0.01). However, expression of TLR2 was not associated with T cell activation. TLR4 expression was similar in patients and healthy controls. In conclusion, TLR2 expression on monocytes and the frequency of T cells expressing TLR2 may contribute to disease progression in chronic HCV infection.
- Subjects
HEPATITIS C virus; TOLL-like receptors; DISEASE progression; HIV-positive persons; HEPATIC fibrosis; T cells
- Publication
APMIS, 2013, Vol 121, Issue 5, p437
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/apm.12013