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- Title
Fetal Atrioventricular Block and Postpartum Augmentative QT Prolongation in a Patient With Long-QT Syndrome With KCNQ1 Mutation.
- Authors
FURUSHIMA, HIROSHI; CHINUSHI, MASAOMI; SATO, AKINORI; AIZAWA, YOSHIFUSA; KIKUCHI, AKIRA; TAKAKUWA, KOICHI; TANAKA, KENICHI
- Abstract
2:1 AV Block in KCNQ1. The case of a 32-year-old pregnant woman, who had had several syncopal episodes during swimming and running at 9 and 10 years of age and whose fetus had 2:1 AV block, is presented. The mother and baby had the same heterozygous single nucleotide substitution in KCNQ1 at T587M. After 27 weeks of gestation, the fetal 2:1 AV block disappeared, and 1:1 AV conduction resumed, with a fetal heart rate of 110-120 beats/min. The maternal electrocardiogram revealed a normal QTc interval (433 ms) without ST-T abnormalities at gestational week 23, but the QTc was 490 and 531 ms at 1 and 2 months postpartum, with biphasic T waves in leads V2 and V3. This case is the first report of fetal 2:1 AV block with KCNQ1 mutation (T587M) and unmasked maternal QT prolongation in the postpartum period. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1170-1173)
- Subjects
SYNCOPE; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HEART block; GENETIC mutation; LONG QT syndrome; EQUIPMENT &; supplies; FETUS; GENETICS; PREGNANCY; HISTORY
- Publication
Journal of Cardiovascular Electrophysiology, 2010, Vol 21, Issue 10, p1170
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1111/j.1540-8167.2010.01758.x