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- Title
Oxidation‐Induced para‐Selective Formylation of N,N‐Substituted Aniline.
- Authors
Sun, Li; Yao, Anjin; Wang, Haiyan; Zhang, Limei; Zeng, Lizhen; Huang, Zhiliang; Gao, Meng; Lei, Aiwen
- Abstract
Abstract: Selective formylation of aromatic C−H bonds is of great importance, since aromatic aldehydes are valuable synthetic intermediates in organic chemistry. Recently, an impressive progress has been made in this field. However, an effective strategy for the selective formylation of N,N‐substituted anilines is still needed. In this regard, we disclose a novel oxidant‐induced para‐selective formylation of N,N‐substituted aniline towards the synthesis of aromatic aldehydes in this work. Using DDQ as the sole oxidant, various N,N‐substituted anilines could be transformed into the desired formylation products under metal‐free conditions, and the yield is up to 92 %.
- Subjects
FORMYLATION; ANILINE; CARBON-hydrogen bonds; AROMATIC aldehydes; SCISSION (Chemistry)
- Publication
Asian Journal of Organic Chemistry, 2018, Vol 7, Issue 8, p1571
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.201800228