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- Title
Toward a solution for cardiac failure in the newborn.
- Authors
Platt, Jeffrey L.; West, Lori J.; Chinnock, Richard E.; Cascalho, Marilia
- Abstract
The newborn infant with severe cardiac failure owed to congenital structural heart disease or cardiomyopathy poses a daunting therapeutic challenge. The ideal solution for both might be cardiac transplantation if availability of hearts was not limiting and if tolerance could be induced, obviating toxicity of immunosuppressive therapy. If one could safely and effectively exploit neonatal tolerance for successful xenotransplantation of the heart, the challenge of severe cardiac failure in the newborn infant might be met. We discuss the need, the potential for applying neonatal tolerance in the setting of xenotransplantation and the possibility that other approaches to this problem might emerge.
- Subjects
HEART failure; TOXICITY testing; HEART diseases; NEWBORN infants; IMMUNOSUPPRESSION
- Publication
Xenotransplantation, 2018, Vol 25, Issue 6, p1
- ISSN
0908-665X
- Publication type
Article
- DOI
10.1111/xen.12479