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- Title
COVID-19 infection and renal injury: where is the place for acute interstitial nephritis disease?
- Authors
León-Román, Juan; Agraz, Irene; Vergara, Ander; Ramos, Natalia; Toapanta, Nestor; García-Carro, Clara; Gabaldón, Alejandra; Bury, Roxana; Bermejo, Sheila; Bestard, Oriol; Soler, María José
- Abstract
Novel coronavirus disease infection (coronavirus disease 2019, COVID-19) was declared a global pandemic in March 2020 and since then has become a major public health problem. The prevalence of COVID-19 infection and acute kidney injury (AKI) is variable depending on several factors such as race/ethnicity and severity of illness. The pathophysiology of renal involvement in COVID-19 infection is not entirely clear, but it could be in part explained by the viral tropism in the kidney parenchyma. AKI in COVID-19 infection can be either by direct invasion of the virus or as a consequence of immunologic response. Diverse studies have focused on the effect of COVID-19 on glomerulonephritis (GN) patients or the 'novo' GN; however, the effect of COVID-19 in acute tubulointerstitial nephritis (ATIN) has been scarcely studied. In this article, we present five cases with different spectrums of COVID-19 infection and ATIN that may suggest that recent diagnosis of ATIN is accompanied by a worse clinical prognosis in comparison with long-term diagnosed ATIN.
- Subjects
COVID-19; INTERSTITIAL nephritis; SARS-CoV-2; COVID-19 pandemic; ACUTE kidney failure; VIRAL tropism
- Publication
Clinical Kidney Journal, 2022, Vol 15, Issue 9, p1698
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfac079