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- Title
Calciphylaxis after kidney transplantation: a rare but life-threatening disorder.
- Authors
Podestà, Manuel Alfredo; Ciceri, Paola; Galassi, Andrea; Cozzolino, Mario
- Abstract
Calciphylaxis is a rare disorder characterized by vascular calcification and thrombosis of the subcutaneous microcirculation, leading to painful necrotic skin lesions and bearing a dreadfully high mortality rate. This syndrome is frequently also termed uraemic calcific arteriolopathy, since most cases are observed in patients with kidney failure. However, it is increasingly clear that calciphylaxis may also affect patients with normal or only slightly impaired renal function, including kidney transplant recipients. A precise definition of the characteristics and risk factors of calciphylaxis developing after kidney transplantation has been hindered by the extreme rarity of this condition, which also hampered the development of effective therapeutic strategies. In the present issue of CKJ , Guillén and colleagues report the largest case series of calciphylaxis in kidney transplant recipients to date, outlining several features that are apparently specific to this population. In this editorial, we briefly present the epidemiology and pathogenesis of calciphylaxis in different patient populations and discuss recent findings for its therapeutic management.
- Subjects
KIDNEY transplantation; ARTERIAL calcification; CALCIPHYLAXIS; PAROXYSMAL hemoglobinuria; KIDNEY failure; KIDNEY physiology
- Publication
Clinical Kidney Journal, 2022, Vol 15, Issue 4, p611
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfab247