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- Title
Cellular immune responses in multiple sclerosis patients treated with interferon-beta.
- Authors
Bustamante, M. F.; Rio, J.; Castro, Z.; Sánchez, A.; Montalban, X.; Comabella, M.
- Abstract
We investigated cellular immune responses at baseline in peripheral blood mononuclear cells ( PBMC) of patients with multiple sclerosis ( MS) treated with interferon ( IFN)-β and classified into responders and non-responders according to clinical response criteria. Levels for IFN-γ, interleukin ( IL)-17 A, IL-17 F, IL-10 and IL-4 were determined in activated PBMC of 10 responders, 10 non-responders and 10 healthy controls by cytometric bead arrays. Cytokine levels in cell culture supernatants were similar between responders and non-responders, and comparable to those obtained in healthy controls. These findings do not support differential cellular immune responses in PBMC at baseline between IFN-β responders and non-responders.
- Subjects
CELLULAR immunity; IMMUNE response; MULTIPLE sclerosis treatment; INTERFERON beta-1a; BLOOD cells; MONONUCLEAR leukocytes; CYTOKINES; CELL culture
- Publication
Clinical & Experimental Immunology, 2013, Vol 171, Issue 3, p243
- ISSN
0009-9104
- Publication type
Article
- DOI
10.1111/cei.12016