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- Title
Silencing of negative regulator of JAK/STAT in colorectal cancer.
- Authors
Endo, Takao; Toyota, Minoru; Imai, Kohzoh
- Abstract
Introduces the article by S. Fujitake, K. Hibi O. Okochi et al. on the aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients. Description of transcriptional silencing, a physiologic process involving the methylation of CpG islands; Examples of a number of genes including tumor suppressor genes being reported to be inactivated in tumors by the epigenetic event in colorectal cancer; Highlights of SOCS-1 acting as a potential tumor suppressor.
- Subjects
METHYLATION; GENE silencing; GENETIC transcription; TUMOR suppressor genes; COLON cancer
- Publication
Journal of Gastroenterology, 2004, Vol 39, Issue 2, p200
- ISSN
0944-1174
- Publication type
editorial
- DOI
10.1007/s00535-004-1276-2