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- Title
Role of positron emission tomography with 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose in evaluating the effects of arterial infusion chemotherapy and radiotherapy on pancreatic cancer.
- Authors
Shibata, Satoshi; Andoh, Hideaki; Yoshioka, Masato; Sato, Tsutomu; Furuya, Tomoki; Asanuma, Yoshihiro; Hatazawa, Jun; Shimosegawa, Eku; Koyama, Kenji; Yamamoto, Yuzo
- Abstract
Background Methods. Ten patients with unresectable pancreatic cancer were enrolled in this study. Computed tomography (CT) and FDG-PET were done before and after CAI (5-fluorouracil [FU], 500 mg/body per day) combined with ERT (50.4 Gy total dose). Tumor regression was evaluated by standardized uptake value (SUV) with FDG-PET, tumor size on CT, and changes in blood levels of carbohydrate antigen (CA) 19-9. The three methods of evaluation were compared. Results. The ten patients were classified in three categories. In category I, tumor changes evident on CT and FDG-PET were consistent. In category II, CT could not accurately detect the area of the tumor. However, tumor uptake on FDG-PET decreased markedly after the treatment in category II patients. In category III, both CT and FDG-PET detected the tumor, as in category I. Although there was no definite change in tumor size on CT, FDG-PET uptake was markedly reduced immediately after the treatment. Reduction in tumor size did not appear on CT until 2 months later. Conclusions. FDG-PET aids in analysis of the effectiveness of chemotherapy and/or radiotherapy. This study evaluated the usefulness of positron emission tomography with 2-deoxy-2-[[sup 18]F]fluoro-d-glucose (FDG-PET) in monitoring the response to continuous arterial infusion chemotherapy (CAI) combined with external radiation therapy (ERT) for unresectable pancreatic carcinomas.
- Subjects
POSITRON emission tomography; PANCREATIC cancer; RADIOTHERAPY; DRUG therapy; TOMOGRAPHY; TUMOR growth; SPONTANEOUS cancer regression
- Publication
Journal of Gastroenterology, 2004, Vol 39, Issue 1, p50
- ISSN
0944-1174
- Publication type
Article