We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
NK026680, a novel compound suppressive of dendritic cell function, ameliorates mortality in acute lethal graft-versus-host reaction in mice.
- Authors
Saiga, K.; Toyoda, E.; Tokunaka, K.; Masuda, A.; Matsumoto, S.; Mashiba, H.; Kuramochi, H.; Nemoto, K.; Abe, F.; Kawagishi, N.; Furukawa, H.; Ono, M.
- Abstract
A role for dendritic cells (DCs) has been emphasized in the onset of acute graft-versus-host disease (GVHD). We have made efforts to develop a new strategy for suppression of DC functions with a chemical compound in the treatment of acute GVHD. We here describe the immunological characterization of the new chemical compound NK026680. It was found that NK026680 significantly suppressed (1) expression of CD83, CD86, and major histocompatibility complex (MHC) class I and II antigens on human monocyte-derived DCs, (2) excretion of interleukin-12p40 on activation of monocyte-derived DCs, (3) allogeneic responses of human and mouse T cells and (4) mortality in mice with acute GVHD evoked across MHC class I or II. The beneficial effect of NK026680 administered orally was without any recognizable adverse effects. Early intervention in acute GVHD was required for this effect, indicating that an early event in acute GVHD is a critical target of NK026680. We propose the use of NK026680 as a prophylactic for acute GVHD.Bone Marrow Transplantation (2006) 37, 317–323. doi:10.1038/sj.bmt.1705231; published online 21 November 2005
- Subjects
GRAFT versus host disease; DENDRITIC cells; MAJOR histocompatibility complex; LYMPHOID tissue; TRANSPLANTATION immunology; LABORATORY mice
- Publication
Bone Marrow Transplantation, 2006, Vol 37, Issue 3, p317
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705231