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- Title
Telomere Length in Adolescent and Young Adult Survivors of Childhood Cancer.
- Authors
Park, Meerim; Lee, Dong-Eun; Hong, Yuna; Suh, Jin Kyung; Lee, Jun Ah; Kim, Myungshin; Park, Hyeon Jin
- Abstract
Simple Summary: Leukocyte relative telomere length (RTL) has not been thoroughly studied among childhood cancer survivors, although survivors are believed to be at risk of telomere attrition due to exposure to cytotoxic cancer treatments. We examined the leukocyte relative telomere length (RTL) in 88 adolescent and young adult childhood cancer survivors. Overall, RTL was not significantly shorter than in age-matched references. However, among 43 patients with hematologic malignancies, those who underwent allogeneic hematopoietic stem cell transplantation had significantly shorter RTL, especially if they developed acute graft-versus-host disease ≥ grade II. Patients with severe or multiple chronic health conditions also had shorter RTL. We examined the leukocyte relative telomere length (RTL) in Korean adolescent and young adult (AYA) survivors of childhood cancer and evaluated the association of leukocyte RTL with multiple factors, including malignancy type, cancer treatment, age, and chronic health conditions (CHCs). Eighty-eight AYA survivors of childhood cancer with a median follow-up period of 73 months were recruited. RTL in pediatric cancer survivors was not significantly shorter than the predicted value for age-matched references. Neither age at diagnosis nor duration of therapy influenced the RTL. Among the 43 patients with hematologic malignancies, those who underwent allogeneic hematopoietic stem cell transplantation (HSCT) showed a significant shortening of the RTL compared with those who did not (p = 0.039). Among the 15 patients who underwent allogeneic HSCT, those who developed acute graft-versus-host disease (GVHD) of grade II or higher had significantly shorter RTL than those who did not (p = 0.012). Patients with grade II CHCs had significantly shorter RTL than those without CHCs or with grade I CHCs (p = 0.001). Survivors with ≥2 CHCs also exhibited shorter RTL (p = 0.027). Overall, pediatric cancer survivors had similar telomere lengths compared to age-matched references. HSCT recipients and patients with severe or multiple CHCs had shorter telomeres. GVHD augmented telomere attrition in HSCT recipients.
- Subjects
SOUTH Korea; LEUCOCYTES; HEMATOPOIETIC stem cell transplantation; TUMORS in children; RESEARCH funding; KRUSKAL-Wallis Test; CANCER patients; DESCRIPTIVE statistics; ANALYSIS of variance; TELOMERES; SURVIVAL analysis (Biometry); REGRESSION analysis; ADOLESCENCE
- Publication
Cancers, 2024, Vol 16, Issue 13, p2344
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16132344