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- Title
The Communication between the PI3K/AKT/mTOR Pathway and Y-Box Binding Protein-1 in Gynecological Cancer.
- Authors
Sobočan, Monika; Bračič, Suzana; Knez, Jure; Takač, Iztok; Haybaeck, Johannes
- Abstract
Studies of the mechanistic (mammalian) target of rapamycin inhibitors (mTOR) represent a step towards the targeted treatment of gynecological cancers. It has been shown that women with increased levels of mTOR signaling pathway targets have worse prognosis compared to women with normal mTOR levels. Yet, targeting mTOR alone has led to unsatisfactory outcomes in gynecological cancer. The aim of our review was therefore to provide an overview of the most recent clinical results and basic findings on the interplay of mTOR signaling and cold shock proteins in gynecological malignancies. Due to their oncogenic activity, there are promising data showing that mTOR and Y-box-protein 1 (YB-1) dual targeting improves the inhibition of carcinogenic activity. Although several components differentially expressed in patients with ovarian, endometrial, and cervical cancer of the mTOR were identified, there are only a few investigated downstream actors in gynecological cancer connecting them with YB-1. Our analysis shows that YB-1 is an important player impacting AKT as well as the downstream actors interacting with mTOR such as epidermal growth factor receptor (EGFR), Snail or E-cadherin.
- Subjects
CARRIER proteins; CELLULAR signal transduction; EPIDERMAL growth factor; FEMALE reproductive organ tumors; GLYCOPROTEINS; OVARIAN tumors; PHOSPHOTRANSFERASES; PROTEIN kinases; CERVIX uteri tumors; ENDOMETRIAL tumors
- Publication
Cancers, 2020, Vol 12, Issue 1, p205
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers12010205