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- Title
Study of Expression Rate of OX40 Gene in Peripheral Blood in Patients with Parkinson's Disease.
- Authors
Seyedjoodak, Azadeh; Alsahebfosoul, Fereshteh; Eskandari, Nahid; Shaygannejadi, Vahid; Salehi, Mansour; Kazemi, Mohammad; Kardi, Mohammad Taghi; Mirmosayyeb, Omid
- Abstract
Objective: Parkinson's disease is a common neurodegenerative disease that mainly affects central nervous system (CNS) and consequently motor system. Inflammation of immune system and CNS has been known as an important predisposing factor for Parkinson's disease. OX40 protein (CD134) is from family of tumor necrosis receptors that acts on T cells surface. Increased expression of this protein has been known as a factor for increase in inflammation and initiation of NF-kappaB signaling pathway in different diseases. This study investigates OX40 gene expression in the patients with Parkinson's disease. Materials and Methods: 20 people with Parkinson's disease and 20 healthy people, as controls, were enrolled in the study. Measurement of OX40 gene expression was conducted by real-time PCR. Results: The mean expression rate of OX40 gene in the patients increased compared to the controls yet insignificantly (p>0.05). Conclusion: The expression of this gene could be helped develop new treatment and prevention approaches through suppression of OX40 gene and OX40L interaction. However, additional clinical, cellular, and interventional studies should be conducted to confirm the treatment approaches.
- Subjects
PARKINSON'S disease; NEURODEGENERATION; CENTRAL nervous system
- Publication
Iranian Journal of Allergy, Asthma & Immunology, 2018, Vol 17, p210
- ISSN
1735-1502
- Publication type
Abstract