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- Title
Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin.
- Authors
Anna-Leena Sirén; Konstantin Radyushkin; Susann Boretius; Daniel Kämmer; Claas-Christian Riechers; Oliver Natt; Derya Sargin; Takashi Watanabe; Swetlana Sperling; Thomas Michaelis; Jack Price; Barbara Meyer; Jens Frahm; Hannelore Ehrenreich
- Abstract
In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection.
- Publication
Brain: A Journal of Neurology, 2006, Vol 129, Issue 2, p480
- ISSN
0006-8950
- Publication type
Article
- DOI
10.1093/brain/awh703