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- Title
Sleep state instabilities in major depressive disorder: Detection and quantification with electrocardiogram-based cardiopulmonary coupling analysis.
- Authors
Yang, Albert C.; Yang, Cheng‐Hung; Hong, Chen‐Jee; Tsai, Shih‐Jen; Kuo, Chung‐Hsun; Peng, Chung‐Kang; Mietus, Joseph E.; Goldberger, Ary L.; Thomas, Robert J.
- Abstract
Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment. We evaluated the utility of electrocardiogram (ECG)-based cardiopulmonary coupling analysis to quantify physiologic sleep stability in patients with major depression. Relative to controls, unmedicated depressed patients had a reduction in high-frequency coupling, an index of stable sleep, an increase in low-frequency coupling, an index of unstable sleep, and an increase in very-low-frequency coupling, an index of wakefulness/REM sleep. The medicated depressed group showed a restoration of stable sleep to a level comparable with that of the control group. ECG-based cardiopulmonary coupling analysis may provide a simple, cost-efficient point-of-care method to quantify sleep quality/stability and to objectively evaluate the severity of insomnia in patients with major depression.
- Subjects
MENTAL depression; SLEEP disorders; AFFECTIVE disorders; PATHOLOGICAL psychology; INSOMNIA; CARDIOPULMONARY system; ELECTROCARDIOGRAPHY
- Publication
Psychophysiology, 2011, Vol 48, Issue 2, p285
- ISSN
0048-5772
- Publication type
Article
- DOI
10.1111/j.1469-8986.2010.01060.x