We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Allo-immunization elicits CD8<sup>+</sup> T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women.
- Authors
Wang, Yufei; Tao, Louisa; Mitchell, Elaine; Bravery, Christopher; Berlingieri, Pasqule; Armstrong, Paul; Vaughan, Robert; Underwood, Jenny; Lehner, Thomas
- Abstract
We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners' mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of CD8 cell-derived suppressor factor activity, RANTES, and macrophage inflammatory proteins 1α and 1β. AIIo-immunization also downregulated the proportion of cells with CCR5 and CXCR4 receptors. We also found a dose-dependent decrease in HIV infectivity of CD4[sup +] cells in vitro after allo-immunization with both primary and T-cell line adapted HIV-1. This study provides a rational basis for an alternative or complementary strategy of allo-immunization against HIV infection.
- Subjects
CD antigens; T cells; CHEMOKINES; HIV-positive women
- Publication
Nature Medicine, 1999, Vol 5, Issue 9, p1004
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/12440