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- Title
Anti-inflammatory effect of caffeic acid, rutin and hypoxoside in C3H mouse model of colitis.
- Authors
Zhong Ye; Henderson, Abigail; Zhiping Liu; Kwangwon Lee; Sun-Ok Lee; Wannemuehler, Michael J.
- Abstract
Susceptibility to inflammatory bowel diseases (e.g. Crohn's disease, ulcerative colitis) involves interactions of the genetic predisposition of the individual and mucosal inflammation. We hypothesized that bioavailable Echinacea and Hypericum phenolics, caffeic acid and rutin, as predicted by anaerobic cecal degradation screening, and hypoxoside (an anti-inflammatory phenolic from African potato) suppressed intestinal damage in a C3H mouse model of colitis. Colitis was induced in C3H/HeOuJ mice (8 wk old, 6 male/6 female per treatment) with 1.25% dextran sodium sulfate (DSS) in drinking water. Rutin or caffeic acid (300 µmol/kg diet) or hypoxoside extract (15 mg/d), were given for 7 d before and during DSS (6 d), as well as without DSS treatment as controls. Colon length, mucosal myeloperoxidase and histopathology scores were compared statistically across treatments to determine the efficacy of the herbal components. Rutin and caffeic acid prevented body weight loss. The colon lengths in phenolic-treated mice (rutin, caffeic acid and hypoxoside) were longer than in DSS-treated controls. Myeloperoxidase was inhibited with each phenolic treatment compared with DSS treated controls. Histological scores of the DSS-treated mice were significantly more severe compared with negative controls. Only caffeic acid caused significantly less severe microscopic lesion scores in colon and cecum than DSS-treated controls based on mucosal height, necrosis, edema, erosion and inflammatory cell infiltration. Thus, caffeic acid-containing foods and herbs might protect against colitis.
- Subjects
PHENOLS; RUTIN; COLITIS; MICE; WEIGHT loss; COLON (Anatomy)
- Publication
FASEB Journal, 2007, Vol 21, Issue 5, pA361
- ISSN
0892-6638
- Publication type
Article