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- Title
Calorie restriction protects against age-related rat aorta sclerosis.
- Authors
Castello, Laura; Froio, Teresa; Cavallini, Gabriella; Biasi, Fiorella; Sapino, Anna; Leonarduzzi, Gabriella; Bergamini, Ettore; Poli, Giuseppe; Chiarpotto, Elena
- Abstract
Investigates whether calorie restriction (CR) might down-regulate fibrosis by preventing oxidant-dependent signaling and consequent fibrogenic stimulus. Effect of CR on age-related increase of oxidative damage and fibrosis in rat aorta; Protection offered by CR against tissue sclerosis through down-regulation of mitogen-activated protein kinases.
- Subjects
LOW-calorie diet; FIBROSIS; COLLAGEN diseases; AORTA; ARTERIES; TISSUES; PROTEIN kinases; LABORATORY rats
- Publication
FASEB Journal, 2005, Vol 19, Issue 13, p1863
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.04-2864fje