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- Title
Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapy.
- Authors
Byoung Yong Shim; Der Sheng Sun; Hye Sung Won; Myung Ah Lee; Soon Uk Hong; Ji-Han Jung; Hyeon-Min Cho; Yoon Ho Ko; Shim, Byoung Yong; Sun, Der Sheng; Won, Hye Sung; Lee, Myung Ah; Hong, Soon Uk; Jung, Ji-Han; Cho, Hyeon-Min; Ko, Yoon Ho
- Abstract
<bold>Background: </bold>Autophagy, a cellular degradation process, has complex roles in tumourigenesis and resistance to cancer treatment in humans. The aim of this study was to explore the expression levels of autophagy-related proteins in patients with rectal cancer and evaluate their clinical role in the neoadjuvant chemoradiotherapy setting.<bold>Methods: </bold>All specimens evaluated were obtained from 101 patients with colorectal cancer who had undergone neoadjuvant chemoradiotherapy and curative surgery. The primary outcomes measured were the expression levels of two autophagy-related proteins (microtubule-associated protein 1 light chain 3 beta (LC3β) and beclin-1) by immunohistochemistry and their association with clinicopathological parameters and patient survival.<bold>Results: </bold>Among the 101 patients, the frequency of high expression of beclin-1 was 31.7% (32/101) and that of LC3β was 46.5% (47/101). A pathologic complete response was inversely associated with LC3β expression (P = 0.003) and alterations in the expression of autophagy-related proteins (P = 0.046). In the multivariate analysis, however, autophagy-related protein expression did not show prognostic significance for relapse-free survival or overall survival.<bold>Conclusions: </bold>High expression of autophagy-related proteins shows a strong negative association with the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer. Autophagy has clear implications as a therapeutic target with which to improve the efficacy of neoadjuvant chemoradiotherapy.
- Subjects
RECTAL cancer; PROTEIN expression; RECTAL cancer patients; CHEMORADIOTHERAPY; CANCER treatment; AUTOPHAGY; CANCER relapse; COMBINED modality therapy; COMPARATIVE studies; GENES; RESEARCH methodology; MEDICAL cooperation; NERVE tissue proteins; PROGNOSIS; RECTUM tumors; RESEARCH; EVALUATION research; PHYSIOLOGICAL effects of radiation
- Publication
BMC Cancer, 2016, Vol 16, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-016-2250-0