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- Title
Site-specific synthesis and application of deuterium-labeled sterols.
- Authors
Muchalski, Hubert
- Abstract
Isotopically-labeled compounds are universally accepted as very useful tracing molecules in chemistry and biology research. They are invaluable to support mechanistic hypotheses and measure reaction rates. Although they did not become mainstream until the early 1960s, numerous scientific contributions, have been made in areas of chemistry and biochemistry by using deuterium-labeled biomolecules. Deuterium-labeled sterols continue to be a primary research tool, particularly at the interface of chemical and biological sciences. This article surveys the literature on the use of deuterium-enriched sterol derivatives with a particular focus on synthetic strategies for incorporation of heavy isotopes.
- Subjects
DEUTERIUM; STEROLS; BIOMOLECULE analysis; STEROLS analysis; RADIOLABELING; KINETIC isotope effects
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2017, Vol 2017, p507
- ISSN
1551-7004
- Publication type
Article
- DOI
10.3998/ark.5550190.p009.755