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- Title
Synthesis, Characterization and DNA Cleaving Studies of New Organocobaloxime Derivatives.
- Authors
Erdem-Tuncmen, Mukadder; Karipcin, Fatma; Ozmen, Ismail
- Abstract
Dioxime ligand (H2L) was synthesized by condensation reaction between 4-biphenylchloroglyoxime and 4-chloroanili-ne. The metal complexes of the types, [Co(HL)2(i-Pr)Py], [CoL2 (i-Pr)PyB2F4] and [CoL2 (i-Pr)Py(Cu(phen))2](ClO4)2 [H2L = 4-(4-chlorophenylamino)biphenylglyoxime; phen = 1,10-phenanthroline; i-Pr = isopropyl; Py = pyridine] were synthesized and characterized by elemental analysis, FT-IR, 1H NMR and magnetic susceptibility, conductivity measurements. The results of elemental analyses, IR and NMR confirmed the stoichiometry of the complexes and the formation of ligand frameworks around the metal ions. The magnetic moment measurements of the complexes indicated that the complexes are diamagnetic (low-spin d6 octahedral) except trinuclear complex. Furthermore the interaction between the dioxime ligand and its complexes with DNA has also been investigated by agarose gel electrophoresis. The trinuclear Cu2Co complex with H2O2 as a cooxidant exhibited the strongest DNA cleaving activity.
- Subjects
DNA; COBALOXIMES; CHEMICAL derivatives; LIGANDS (Chemistry); ORGANIC synthesis; METAL complexes; FOURIER transform infrared spectroscopy; MAGNETIC susceptibility
- Publication
Acta Chimica Slovenica, 2013, Vol 60, Issue 1, p131
- ISSN
1318-0207
- Publication type
Article