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- Title
Measurement of endometrial and uterine vascularity by transvaginal ultrasonography in predicting pregnancy outcome during frozen-thawed embryo transfer cycles.
- Authors
Son, Jung Bin; Jeong, Ju Eun; Joo, Jong Kil; Na, Yong Jin; Kim, Chang Woon; Lee, Kyu Sup
- Abstract
Aim An appropriate endometrial condition and vascular supply are usually considered essential for implantation of an embryo. This study was performed to assess the role of endometrial and uterine vascularity status measurement in predicting pregnancy outcome during frozen-thawed embryo transfer cycles. Material and Methods A total of 70 infertile women were recruited with controlled ovarian stimulation followed by oocyte retrieval. After in vitro fertilization or intracytoplasmic sperm injection, embryos were cultured to blastocysts and blastocysts with good quality were selected for cryopreservation. After endometrial preparation, vitrified blastocysts were thawed and assisted hatching by zona dissection was performed. On the day of embryo transfer, endometrial thickness ( EMT), resistance index ( RI) and pulsatility index ( PI) of sub-endometrial artery ( SEA) and uterine artery ( UA) were obtained by transvaginal sonography. The women were divided into the pregnant and non-pregnant groups, and these variables were compared between the two groups. Results Patients' general demographic characteristics were not statistically different between the pregnant and non-pregnant groups. The overall implantation rate, clinical pregnancy rate, and ongoing pregnancy rate were 31.1%, 41.4% and 28.6%, respectively. Twenty-nine patients who conceived had average EMT, RI of SEA, PI of SEA, RI of UA, and PI of UA values of 9.15 mm, 0.91, 2.42, 0.95, and 3.37, respectively. Forty-one patients who did not conceive had average EMT, RI of SEA, PI of SEA, RI of UA, and PI of UA values of 9.31 mm, 1.01, 2.56, 0.94, and 3.00, respectively. In the two groups, none of the variables was statistically different ( P > 0.05). Conclusions EMT and blood flow index of endometrium and uterus measured by transvaginal sonography are not an effective predictor of pregnancy outcome in frozen-thawed embryo transfer cycles.
- Subjects
ENDOMETRIUM physiology; UTERUS physiology; ENDOSCOPIC ultrasonography; ACADEMIC medical centers; CELL culture; EMBRYO transfer; FERTILIZATION in vitro; LONGITUDINAL method; EVALUATION of medical care; PREGNANCY; RESEARCH funding; T-test (Statistics); DATA analysis software; DESCRIPTIVE statistics
- Publication
Journal of Obstetrics & Gynaecology Research, 2014, Vol 40, Issue 6, p1661
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.12406