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- Title
Does skin prick test response intensity predict symptom severity and efficacy of subcutaneous immunotherapy in allergic rhinitis?
- Authors
Yuan, Xuan; Xie, Shaobing; Meng, Lai; Zhong, Wei; Zhang, Hua; Wang, Fengjun; Fan, Ruohao; Jiang, Weihong; Xie, Zhihai
- Abstract
Objectives: To investigate the effect of response intensity of allergen skin prick test (SPT) on symptom severity and long-term efficacy of dust mite subcutaneous immunotherapy (SCIT) in allergic rhinitis (AR). Methods: AR Patients diagnosed with dust mite allergy and completed 3 years of SCIT were collected and classified into three groups: grade 2 (SPT of + +), grade 3 (SPT of + + +) and grade 4 (SPT of + + + +). Comparisons between groups were performed to examine the associations of SPT categories and symptom severity and the long-term efficacy of SCIT in AR. Results: 181 AR patients were included. There was no significant difference in the baseline TNSS, SMS, RQLQ and VAS, and particularly to symptom severity grading among three SPT grade groups (P > 0.05). The moderate–severe AR was more likely to be smoking and accompany with asthma and had higher prevalence of sensitization to cockroach, mixed grass and tree pollen than mild AR (P < 0.05). Prevalence of sensitization to cockroach, mixed grass, ragweed and animal dander was increased in AR patients with asthma and allergic conjunctivitis (P < 0.05). Furthermore, after 3 years of SCIT, no statistical differences in TNSS, SMS, RQLQ, VAS and long-term efficacy were observed among the three SPT grade groups (P > 0.05). Similarly, long-term outcomes of patients with different SPT grades did not differ among different clinical characteristics and different efficacy determination criteria (P > 0.05). Conclusions: The SPT response intensity cannot be used as an objective evaluation index for symptom severity and the long-term efficacy of SCIT in AR patients.
- Subjects
ALLERGIC rhinitis; SKIN tests; SYMPTOMS; IMMUNOTHERAPY; ASTHMATICS; ALLERGIC conjunctivitis; WHEEZE
- Publication
European Archives of Oto-Rhino-Laryngology, 2024, Vol 281, Issue 2, p767
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-023-08220-5