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- Title
2-Hydroxy-oestradiol-17β as a possible link in steroid brain interaction.
- Authors
PARVIZI, NAHID; ELLENDORFF, FRANZ
- Abstract
IN spite of wide evidence for their existence, mechanisms of steroid-brain interaction are poorly understood. It has been reported that hydroxylation of oestrogens occurs in the liver1,2 and that hydroxylated oestrogens such as 2-hydroxy-oestradiol-17β (2-OHE2) are strong competitive inhibitors of the methylation of catecholamines by catechol-O-methyltransferase3. We report for the first time the action of 2-OHE2 on the brain. Our experiments demonstrate that 2-OHE2 lowered plasma levels of the anterior pituitary luteinising hormone (LH). A response was recorded from the amygdala, which accumulate gonadal steroids4,5 and participate in the regulation of the anterior pituitary.
- Publication
Nature, 1975, Vol 256, Issue 5512, p59
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/256059a0