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- Title
Unveiling Silent Consequences: Impact of Pulmonary Tuberculosis on Lung Health and Functional Wellbeing after Treatment.
- Authors
Bansal, Nidhi; Arunachala, Sumalatha; Kaleem Ullah, Mohammed; Kulkarni, Shreedhar; Ravindran, Sukanya; ShankaraSetty, Rekha Vaddarahalli; Malamardi, Sowmya; Chaya, Sindaghatta Krishnarao; Lokesh, Komarla Sundararaja; Parthasarathi, Ashwaghosha; Shyam Prasad Shetty, Bellipady; Chikkahonnaiah, Prashanth; Vishwanath, Prashant; Siddaiah, Jayaraj Biligere; Mahesh, Padukudru Anand
- Abstract
Background: Pulmonary tuberculosis (TB) remains a major public health issue in India, with high incidence and mortality. The current literature on post-TB sequelae functional defects focuses heavily on spirometry, with conflicting obstruction vs. restriction data, lacks advanced statistical analysis, and has insufficient data on diffusion limitation and functional impairment. Objective: This study aimed to thoroughly evaluate post-tubercular sequelae after treatment, assessing chest radiology, spirometry, diffusing capacity, and exercise capacity. Methods: A total of 85 patients were studied at a university teaching hospital in Mysuru. The data collected included characteristics, comorbidities, smoking history, and respiratory symptoms. The investigations included spirometry, DLCO, chest X-rays with scoring, and 6MWT. Results: Of the patients, 70% had abnormal X-rays post-treatment, correlating with reduced lung function. Additionally, 70% had impaired spirometry with obstructive/restrictive patterns, and 62.2% had reduced DLCO, with females at higher risk. Smoking increased the risk of sequelae. Conclusions: Most patients had residual radiological/lung function abnormalities post-treatment. Advanced analyses provide insights into obstructive vs. restrictive defects. Ongoing research should explore pathogenetic mechanisms and therapeutic modalities to minimize long-term post-TB disability.
- Subjects
TUBERCULOSIS; PUBLIC health; AEROBIC capacity; TEACHING hospitals; SPIROMETRY
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 14, p4115
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13144115