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- Title
Fetal Bradycardia Caused by Monogenic Disorders—A Review of the Literature.
- Authors
Westphal, Dominik S.; Hauser, Michael; Beckmann, Britt-Maria; Wolf, Cordula M.; Hessling, Gabriele; Oberhoffer-Fritz, Renate; Wacker-Gussmann, Annette
- Abstract
Introduction: The standard obstetric definition of fetal bradycardia is a sustained fetal heart rate < 110 bpm over at least 10 min. Fetal bradycardia can be the first and only prenatal presentation of a heart disease. We present an overview on different genetic disorders that should be taken into consideration in case of diagnosed fetal bradycardia. Methods: A literature review was conducted using a PubMed- and OMIM-based search for monogenetic disorders causing fetal bradycardia in September 2022. Results: The review on the literature identified nine monogenic diseases that could lead to fetal bradycardia. Four of these disorders can be associated with extracardiac findings. Discussion: Genetic testing should be considered in cases with fetal bradycardia, especially in cases of additional extracardiac findings. Broad sequencing techniques and improved prenatal phenotyping could help to establish a diagnosis in an increasing number of cases.
- Subjects
BRADYCARDIA; LITERATURE reviews; FETAL heart rate; GENETIC disorders; HEART diseases
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 23, p6880
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11236880