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- Title
Preclinical Advances of Therapies for Laminopathies.
- Authors
Benarroch, Louise; Cohen, Enzo; Atalaia, Antonio; Ben Yaou, Rabah; Bonne, Gisèle; Bertrand, Anne T
- Abstract
Laminopathies are a group of rare disorders due to mutation in LMNA gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for laminopathies are not fully understood, several therapeutic approaches have been evaluated in patient cells or animal models, ranging from gene therapies to cell and drug therapies. This review is focused on these therapies with a strong focus on striated muscle laminopathies and premature ageing syndromes.
- Subjects
THERAPEUTICS; STRIATED muscle; PREMATURE aging (Medicine); ADIPOSE tissues; DRUG therapy; NEMALINE myopathy
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 21, p4834
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10214834