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- Title
Blocking Endogenous Glypican-3 Expression Releases Hep 3B Cells from G1 Arrest.
- Authors
Farooq, Mohammad; Hwang, Sun Young; Park, Mi Kyung; Kim, Juno-Chul; Kim, Moon Kyu; Sung, Young Kwan
- Abstract
Glypican-3 (GPC3) encodes a cell-surface heparansulfate proteoglycan mutated in type 1 SimpsonGolabi-Behmel syndrome (SGBSI), an X-linked overgrowth syndrome. The phenotype of SGBSI patients and of GPC3 knockout mice suggests that GPC3 plays a negative role in cell proliferation, and an apoptosisinducing role in specific tissues. Ectopic expression of (;PC3 in some cell lines has supported the idea that GPC3 inhibits cell growth. Here we report that blocking endogenous GPC3 expression with an antisense transcript promotes the growth of Hep G2 and Hep 3B hepatoma cell lines. Moreover, antisense inhibition releases Hep 3B cells from cell cycle arrest. Hence, our data further support the notion that GPC3 is an inhibitor of cell proliferation and demonstrate that it modulates cell cycle progression.
- Subjects
PROTEOGLYCANS; GLYCOPROTEINS; CELL proliferation; MOLECULAR genetics; MOLECULAR biology
- Publication
Molecules & Cells (Springer Nature), 2003, Vol 15, Issue 3, p356
- ISSN
1016-8478
- Publication type
Article
- DOI
10.1016/s1016-8478(23)13749-6