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- Title
SARS‐CoV‐2‐specific IgG1/IgG3 but not IgM in children with Pediatric Inflammatory Multi‐System Syndrome.
- Authors
Perez‐Toledo, Marisol; Faustini, Sian E.; Jossi, Sian E.; Shields, Adrian M.; Marcial‐Juarez, Edith; Kanthimathinathan, Hari Krishnan; Allen, Joel D.; Watanabe, Yasunori; Goodall, Margaret; Willcox, Benjamin E.; Willcox, Carrie R.; Salim, Mahboob; Wraith, David C.; Veenith, Tonny V.; Syrimi, Eleni; Drayson, Mark T.; Jyothish, Deepthi; Al‐Abadi, Eslam; Chikermane, Ashish; Welch, Steven B.
- Abstract
Although anti-S IgA and IgG were more similar in children and adult COVID-19 patients, anti-N IgA and IgG antibodies were higher in ITU patients (Figure 1C,D). Since antibody isotypes can reflect recent infection (IgM), or more historic infections (IgG and IgA), we examined individual antibody isotypes and presented these results as area under the curve (AUC). Therefore, children with Kawasaki-like inflammatory syndrome, negative by PCR, can have IgG1, IgG3, and IgA antibody levels to SARS-CoV-2 in the absence of maintained IgM responses. Screening of sera, diluted 1:40, to detect IgG, IgA, and IgM demonstrated that all children had antibodies against the SARS-CoV-2 S glycoprotein (Figure 1A).
- Subjects
COVID-19; CHILD patients; TOXIC shock syndrome; MEDICAL personnel; VIRAL antibodies
- Publication
Pediatric Allergy & Immunology, 2021, Vol 32, Issue 5, p1125
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.13504