We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Severity of rhinitis and wheezing is strongly associated in preschoolers: A population-based study.
- Authors
Pereira, Ana Margarida; Morais‐Almeida, Mário; Santos, Natacha; Nunes, Carlos; Bousquet, Jean; Fonseca, João Almeida
- Abstract
Background In preschool children, no study assessed the relation between wheezing and rhinitis severity. Our aims were to estimate the prevalence of current wheezing ( CW) in preschoolers and to study the association between CW and current rhinitis ( CR), considering its severity/persistency. Methods This is a cross-sectional, nationwide, population-based study including a representative sample of 5003 Portuguese children aged 3-5 years. Data were collected by a face-to-face interview with caregivers using an adapted ISAAC questionnaire. CW was defined as presence of ≥1 wheezing episode in the previous 12 months. Rhinitis severity/persistency was classified according to Allergic Rhinitis and its Impact on Asthma. Results Current wheezing prevalence was 24.5% [95% CI 23.3-25.7]; 9.4% of the participants had ≥4 wheezing episodes in the previous year. Children with CR had an odds ratio ( OR) of 4.0 [95% CI 3.4-4.5] for CW; it was highest for children with moderate-severe persistent rhinitis (11.5 [95% CI 8.1-16.3]), even after adjusting for possible confounders. Wheezers with CR reported more wheezing treatment use (p = 0.024) than those without CR. There was a trend for a higher number of wheezing episodes with more persistent and severe nasal disease - 48.4% of children with moderate-severe persistent rhinitis had >4 wheezing episodes vs. 28.9% in moderate-severe intermittent, 20.0% in mild persistent, 10.8% in mild intermittent, and 3.6% in those without CR; p < 0.001. Conclusions Current wheezing was present in almost 25% of preschool children and was strongly associated with rhinitis, especially moderate-severe persistent disease. Preschoolers with both CW and rhinitis seem to have a more severe phenotype, emphasizing the need for concurrent evaluation of nasal and bronchial symptoms even in small children.
- Subjects
RHINITIS; WHEEZE; PRESCHOOL children; NOSE diseases; MALTHUSIANISM
- Publication
Pediatric Allergy & Immunology, 2015, Vol 26, Issue 7, p618
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12430