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- Title
Co-administration of salbutamol and fluticasone for emergency treatment of children with moderate acute asthma.
- Authors
Estrada-Reyes, Elizabeth; Del Río-Navarro, Blanca E.; Rosas-Vargas, Miguel Angel; Nava-Ocampo, Alejandro A.
- Abstract
This study aimed to compare the efficacy of nebulized therapy with salbutamol alone or in combination with fluticasone. In a randomized, double-blind clinical trial, 150 children with moderate acute asthma were randomly assigned to receive by nebulizations either (i) three doses of salbutamol 30 μl/kg per dose, each dose administered every 15 min, (ii) three doses of salbutamol plus two doses of fluticasone 500 μg/dose at 15 and 30 min after first dose of salbutamol, or (iii) three doses of salbutamol/fluticasone 500 μg/dose, each combined dose administered every 15 min. Pulse oxymetry (SaO2), peak expiratory flow (PEF) and Wood et al. ( Am J Dis Child, 123, 1972, 123) clinical scale were evaluated at baseline, 15, 30, 45, 60, 90 and 120 min after the first nebulization. Patients in the three groups significantly improved since 15 min after the first nebulization. We did not observe differences in the recovery of SaO2 and PEF among the three groups of treatment (p > 0.10). In group 3, children showed better clinical response at 120 min than the other two groups (p < 0.05). No significant adverse effects were observed with any treatment. To summarize, in children with acute moderate asthma, nebulized salbutamol at an accumulated dose of 90 μl/kg plus fluticasone at an accumulated dose of 1500 μg produced better clinical relief after 2 h. However, similar PEF and SaO2 responses were observed with salbutamol alone or in combination with different doses of fluticasone.
- Subjects
ASTHMA; BRONCHIAL diseases; ASTHMA in children; OBSTRUCTIVE lung diseases; BRONCHODILATOR agents; ANTIASTHMATIC agents; ALLERGY in children
- Publication
Pediatric Allergy & Immunology, 2005, Vol 16, Issue 7, p609
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/j.1399-3038.2005.00317.x