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- Title
Mitochondria in Myelinating Oligodendrocytes: Slow and Out of Breath?
- Authors
Meyer, Niklas; Rinholm, Johanne Egge
- Abstract
Myelin is a lipid-rich membrane that wraps around axons and facilitates rapid action potential propagation. In the brain, myelin is synthesized and maintained by oligodendrocytes. These cells have a high metabolic demand that requires mitochondrial ATP production during the process of myelination, but they rely less on mitochondrial respiration after myelination is complete. Mitochondria change in morphology and distribution during oligodendrocyte development. Furthermore, the morphology and dynamic properties of mitochondria in mature oligodendrocytes seem different from any other brain cell. Here, we first give a brief introduction to oligodendrocyte biology and function. We then review the current knowledge on oligodendrocyte metabolism and discuss how the available data on mitochondrial morphology and mobility as well as transcriptome and proteome studies can shed light on the metabolic properties of oligodendrocytes.
- Subjects
MITOCHONDRIA; OLIGODENDROGLIA; SUPPLY &; demand; MORPHOLOGY; MYELINATION; BIOLOGY; CELL metabolism
- Publication
Metabolites (2218-1989), 2021, Vol 11, Issue 6, p359
- ISSN
2218-1989
- Publication type
Article
- DOI
10.3390/metabo11060359